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Manganic encephalopathy due to "ephedrone" abuse.

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Manganic encephalopathy due to "ephedrone" abuse.

Auteurs : Yanush Sanotsky [Ukraine] ; Roman Lesyk ; Lyudmyla Fedoryshyn ; Iryna Komnatska ; Yuriy Matviyenko ; Stanley Fahn

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2007.

RBID : pubmed:17566121

English descriptors

KwdEn :
- Adult, Basal Ganglia (pathology), Brain Diseases (etiology), Brain Diseases (pathology), Humans, Magnetic Resonance Imaging, Male, Manganese Poisoning (complications), Middle Aged, Propiophenones (adverse effects), Retrospective Studies, Substance-Related Disorders (complications), Substance-Related Disorders (etiology).
MESH :
- chemical , adverse effects : Propiophenones.
- complications : Manganese Poisoning, Substance-Related Disorders.
- etiology : Brain Diseases, Substance-Related Disorders.
- pathology : Basal Ganglia, Brain Diseases.
- Adult, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies.

Abstract

We describe the clinical and neuroimaging features of 6 drug-abuse patients with self-inflicted manganese poisoning. The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.

DOI: 10.1002/mds.21378
PubMed: 17566121

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Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Manganic encephalopathy due to "ephedrone" abuse.</title>
<author><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Lviv Regional Clinical Hospital, Lviv, Ukraine. janush_s@yahoo.com</nlm:affiliation>
<country xml:lang="fr">Ukraine</country>
<wicri:regionArea>Department of Neurology, Lviv Regional Clinical Hospital, Lviv</wicri:regionArea>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lesyk, Roman" sort="Lesyk, Roman" uniqKey="Lesyk R" first="Roman" last="Lesyk">Roman Lesyk</name>
</author>
<author><name sortKey="Fedoryshyn, Lyudmyla" sort="Fedoryshyn, Lyudmyla" uniqKey="Fedoryshyn L" first="Lyudmyla" last="Fedoryshyn">Lyudmyla Fedoryshyn</name>
</author>
<author><name sortKey="Komnatska, Iryna" sort="Komnatska, Iryna" uniqKey="Komnatska I" first="Iryna" last="Komnatska">Iryna Komnatska</name>
</author>
<author><name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name>
</author>
<author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
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<author><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name>
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<author><name sortKey="Lesyk, Roman" sort="Lesyk, Roman" uniqKey="Lesyk R" first="Roman" last="Lesyk">Roman Lesyk</name>
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<author><name sortKey="Fedoryshyn, Lyudmyla" sort="Fedoryshyn, Lyudmyla" uniqKey="Fedoryshyn L" first="Lyudmyla" last="Fedoryshyn">Lyudmyla Fedoryshyn</name>
</author>
<author><name sortKey="Komnatska, Iryna" sort="Komnatska, Iryna" uniqKey="Komnatska I" first="Iryna" last="Komnatska">Iryna Komnatska</name>
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<author><name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name>
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<author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Basal Ganglia (pathology)</term>
<term>Brain Diseases (etiology)</term>
<term>Brain Diseases (pathology)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Manganese Poisoning (complications)</term>
<term>Middle Aged</term>
<term>Propiophenones (adverse effects)</term>
<term>Retrospective Studies</term>
<term>Substance-Related Disorders (complications)</term>
<term>Substance-Related Disorders (etiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Propiophenones</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Manganese Poisoning</term>
<term>Substance-Related Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Brain Diseases</term>
<term>Substance-Related Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Brain Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
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<front><div type="abstract" xml:lang="en">We describe the clinical and neuroimaging features of 6 drug-abuse patients with self-inflicted manganese poisoning. The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.</div>
</front>
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<Month>07</Month>
<Day>30</Day>
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<DateCompleted><Year>2008</Year>
<Month>04</Month>
<Day>16</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>22</Volume>
<Issue>9</Issue>
<PubDate><Year>2007</Year>
<Month>Jul</Month>
<Day>15</Day>
</PubDate>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Manganic encephalopathy due to "ephedrone" abuse.</ArticleTitle>
<Pagination><MedlinePgn>1337-43</MedlinePgn>
</Pagination>
<Abstract><AbstractText>We describe the clinical and neuroimaging features of 6 drug-abuse patients with self-inflicted manganese poisoning. The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.</AbstractText>
<CopyrightInformation>2007 Movement Disorder Society</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sanotsky</LastName>
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<Author ValidYN="Y"><LastName>Fahn</LastName>
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<Language>eng</Language>
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<MedlineJournalInfo><Country>United States</Country>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012189">Retrospective Studies</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D019966">Substance-Related Disorders</DescriptorName>
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<tree><noCountry><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
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<name sortKey="Lesyk, Roman" sort="Lesyk, Roman" uniqKey="Lesyk R" first="Roman" last="Lesyk">Roman Lesyk</name>
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<country name="Ukraine"><noRegion><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Manganic encephalopathy due to "ephedrone" abuse.

Manganic encephalopathy due to "ephedrone" abuse.

Source :

English descriptors

Abstract

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